Environmental toxins and their influence on mitochondrial function
Dr. med. Jila Maki, Specialist in General Medicine, Datteln, Germany
New diseases – gene polymorphism, mitochondrial dysfunction, mental and
endocrine disorders — and the therapy protocol with BICOM® bioresonance
therapy
Environmental toxins and stress medicine
Clinical pictures have changed drastically in the last 20-30 years. We are no longer talking about common clinical pictures that are the result of certain natural pathogens such as viruses, bacteria, parasites or certain types of fungi, but about clinical pictures that are not really definable as they represent complex clinical pictures.
Why is this?
The natural enemies that our body has known for millions of years have certain surface structures such as polysaccharides and protein structures, against which our body has developed different strategies over the course of time.
Since the beginning of industrialization, however, we have been increasingly burdened by other pollutants that are growing exponentially in number and toxicity and for which our identification systems are not trained. Today it is chemicals, heavy metals, light metals, phthalates, pesticides, herbicides (glyphosate), radiation and electromagnetic fields that are particularly harmful to us.
These pollutants can bind to the body’s own structures such as proteins or enzymes and damage them. Mercury, for example, binds to the sulphur side chains of an enzyme. This results in a sulphur-sulphur bond (disulphide bridge formation) and the enzyme becomes oxidized or deactivated. Over time, these changes can lead to a change in the genetic information for enzyme formation.
For decades, toxicologists have measured the influence of pollutants or toxins in toxic or lethal quantities. However, what they have failed to point out is what happens to the body when it is exposed to one or more such substances in small quantities but on a daily basis. This is exactly what regularly happens in our domestic environment or in the workplace. Although the quantity of the individual substances here is generally below the lethal dose, this does not alter their
overall toxicity. In addition, there are differences in tolerance capacity as one human body may be able to detoxify better than another.
Another factor is the high number of pollutants. An article from 1996 for example reported 65,000 chemicals in everyday use. Dr. Kurt Miller, one of the most renowned toxicologists in Germany, reported in an article from 2004 that there are 120,000 foreign substances in the everyday lives of Germans. We currently have over 4 million pollutants, of which around 300,000 to 360,000 are chemicals. Many of these we are are exposed to on a daily basis.
We do not know what influence these pollutants have in combination, as the laboratories can only measure a maximum of five substances in combination. What is certain, however, is that the harmful influence of substances in combination is not just additive, but actually multiplicative or exponential. In a conventionally grown salad, for example, around 10-16 pesticides are used, none of which exceed the limit value, but what does the combination do? What impact does this combination of pesticides have on our health?
In terms of evolutionary history, we are able to neutralize and reuse or dispose of the endogenous pollutants that we produce during metabolic processes. If our endogenous enzyme system is however now additionally stressed by exogenous toxic substances, this leads to a shortage of enzymes for the neutralization of endogenous toxic substances. As a result, we are no longer
sufficiently capable of eliminating our own pollutants and we pollute from the inside.
Environmental toxins and detoxification processes
How does a detoxification process work?
The detoxification mechanism has two phases:
In phase | of detoxification, apolar and lipophilic substances are converted into polar and hydrophilic substances (metabolism, functionalization reaction or conversion reaction). This process takes place through oxidation, reduction and hydrolysis. The enzymes that catalyze this phase belong to the cytochrome P450 groups. The harmful substances are activated and there is increased reactivity. If these substances are not metabolized quickly during phase |, cellular components and base pairs in the DNA strand, proteins and lipids may be damaged. These water-soluble and polar intermediates are highly reactive and have oxidative, mutagenic and carcinogenic properties. They can lead to countless immunological reactions, which ultimately provide us with complex patterns of disease.
In phase Il of detoxification, a conjugation reaction takes place. Foreign substances or the body’s own metabolites are made water-soluble through methylation, glucuronidation, sulphation, acetylation and conjugation. They form amino acids or glutathione and are partly excreted through the bile, intestines or kidneys. One of the most important enzymes in phase Il of detoxification are glutathione S-transferase enzymes.
The performance of the individual enzymes in phase | and phase Il of detoxification is of upmost importance here. The gene polymorphism in the GSTM1, T1 and P1 genes has been best studied.
Carriers of a homozygous deletion of this enzyme show an increased risk of cancer, neurodegenerative diseases such as Alzheimer’s, Parkinson’s, metabolic syndrome, i.e. diabetes, coronary arteriosclerosis and countless inflammatory diseases in the joints and skeletal system.
Meta-analyses show that the number of people with polymorphisms is also increasing exponentially. Based on the study, 50% of test subjects have a deletion of the glutathione S-transferase M1 gene and 15-20% of test subjects have a deletion of glutathione S-transferase T1.
The contamination of air, water and food with highly lipophilic and persistent xenobiotics and the associated heavy strain on the detoxification process are therefore a major cause in the development of chronic multisystemic diseases.
Environmental toxins and immune defense
When it comes to immune defense, we distinguish between the innate and acquired immune system.
As part of the innate immune system, active cells, including monocytes in the blood, macrophages in the tissue and neutrophil granulocytes, can recognize and destroy large particle organisms such as bacteria. One way of successfully fighting a local infection is through the recruitment of monocytic cells and neutrophils by chemokines, i.e. the release of pro-inflammatory mediators or cytokines such as interleukin 1B, IL-6, IL8, tumor necrosis factor alpha (TNF-a). Another important component of the innate immune system are the natural killer cells (NK cells).
These specialize in identifying and eliminating virus-infected cells and malignant tumour cells. It is assumed that 90% of all infections can be recognized and successfully combated in this way.
In the acquired immune system, we are familiar with the T and B lymphocytes. T lymphocytes make up the majority of lymphocytes in the blood (60-80%). They are responsible for the so-called cellular immune response. The T cell reacts directly to a foreign antigen. These can be cells infected by viruses or tumor cells. B lymphocytes produce antibodies that circulate in the blood and are distributed throughout the body. Antibodies are a kind of special defensive unit with built-in enemy recognition. They bind specifically to the foreign antigen and thus inactivate viruses or bacterial toxins.
T and B lymphocytes are characterized by the fact that they react specifically to individual structures of pathogens (antigens). The diversity of antigen recognition and thus the adaptability of the acquired immune system to an unknown enemy is extremely high. After initial activation, the T and B lymphocytes undergo a phase of expansion. This means that a specific cell gives rise to a population of cells that all have the same specificity as the original cell and can survive in the body for some time (memory lymphocytes).
Environmental toxins and stress medicine
How does the body deal with new adversaries such as electromagnetic fields, stress, etc.?
The body’s distribution mechanisms are immunological, physical, enzymatic and biochemical. These new enemies have no protein structure on their surfaces. The body therefore targets these enemies with general weapons that have no selectivity. These include a number of cytokines such as interleukin 1B, interleukin 6, interleukin 8 and tumor necrosis factor, all of which belong to the inflammatory defense group. In addition, there are tolerance groups such as interleukin 4, 5 and
interleukin 10, which have the task of slowing down these enemies.
In this defense mechanism, the body does not act selectively, i.e. not only against the specific enemy, but also partly against its own body tissues. The result is silent inflammation. Patients feel feverish, especially at night, without actually having a fever. These processes cannot be detected with usual laboratory values, which is why these patients often go unnoticed.
Environmental toxins, hyperimmunity and ATP loss
Many enzymes are activated when combating exogenous toxins, and their activity draws a considerable amount of cellular energy from the body. Under normal stress, our body always endeavors to use energy economically. During such processes, however, it abandons all economic principles. To do this, the body needs a number of enzymes such as catechol-O-methyltransferase (COMT), X-linked monoamine oxidase-A (MAO-A) or glutathione S-transferase enzymes.
We see increased polymorphism of these enzymes and therefore considerable losses in mitochondrial ATP formation. The mitochondria, which themselves need ATP for their regeneration and synthesis, lose their original form.
We age faster and are more susceptible to pathogens. This leads to exhaustion of the neuroendocrine system and so-called chronic fatigue syndrome, which is reflected in multiple clinical pictures. These include irritable bowel syndrome (leaky gut syndrome), recurrent viral infections such as herpes zoster or chronic bacterial infections such as urinary tract infections, colpitis, frequent recurrent swelling of the lymph nodes, myopathies, dysfunction of the nervous system, muscle atrophies, metabolic diseases such as diabetes mellitus and hormonal and endocrine disorders.
In addition, the number of people with autism, children with ADHD, depression and anxiety disorders is on the rise. People are increasingly losing their resilience to environmental factors and report general weakness, exhaustion and weakness.
Mitochondria
Mitochondria are the body’s small bio-power plants. Energy production takes place through oxidative phosphorylation in the respiratory chain and through B-oxidation of fatty acids
They have their own DNA (mtDNA), without repair mechanisms, coded for 13 proteins
Synthesis of iron-sulfur centers, individual As and heme biosynthesis
Initiation and monitoring of cell apoptosis
Mitochondrial DNA is inherited exclusively from the mother’s side
Mitochondria are involved in the synthesis of steroid hormones
Without mitochondria there is no energy and no life
Ahealthy adult converts approx. 3000 times ADP to ATP per day. In kilograms, this is roughly equivalent to your own body weight
Mitochondria have an oval shape, they are egg-shaped. Their outer membrane is smooth, the inner membrane has many folds that increase the surface area, and in between is the intermembrane space. Respiratory chains are built into the interior. Mitochondria can expand or reduce these folds.
Mitochondria are predominantly transmitted from the mother, with a small proportion from the father. Our mitochondria therefore still contain genetic information from the original Eve. The mitochondrial DNA has a ring shape and is exposed, which makes it susceptible to damage.The cell nucleus is crumpled up. Mutations can therefore occur. Mitochondria are immigrated cell organelles. It is assumed that mitochondria migrated into the cell as eukaryotes and that they developed into cell organelles there. The mitochondria contribute significantly to the function of all cells with their metabolic processes.
Mitochondria act like sensors. They receive a lot of information from cytokines and other messenger substances, toxins and free radicals. They can, for example, stop functioning in the event of increased stress in order to protect themselves from free radicals. In this case they need to be counteracted by good antioxidant capacity in the event of increased energy requirements.The first mt-DNA is said to have been homoplastic, i.e. the same in all cells. However, the ring form of the mt DNA is susceptible to damage, which can result in mutations. These changes, which also take place in the egg cells, lead to a heteroplastic composition, which can result in polymorphisms.
Oxidative and nitrosative stress
As with all energy production, reactive oxygen species (ROS) and reactive nitrogen species (RNS) are produced in the mitochondria as a result of various metabolic processes. Problems arise when too many ROS are formed (due to mitochondrial dysfunction) or when there are too few antioxidant detoxification functions. Heavy metals, nanoparticles and extreme stress reactions are involved in both malfunctions.
The ring-shaped mtDNA is contained in the mitochondrial matrix and is very susceptible to damaging reagents. The damaging substances block the enzyme activity of the respiratory chains and increase the permeability of the inner mitochondrial membrane. As a result, cytochrome-C, a cytotoxic substance, is released into the cytosol. Cytochrome-C leads to premature apoptosis and
a resulting lack of ATP production.This loss of energy leads to numerous symptoms such as physical exhaustion, fatigue and listlessness. If this process is not remedied in time, chronic illnesses will follow.
Therapeutic measures
In addition to countless measures (such as diet, outdoor exercise, detoxification therapies with homeopathic complexes, herbal therapy, chelation therapies, the administration of micronutrients in oral form or via infusions, the improvement of mitochondrial renewal with IHHT (Intermittent Hypoxia-Hyperoxia Therapy), the administration of bioidentical hormone therapies for hormonal dysfunction), we therapists should think about energetic and cellular blockages. As long as these
blockages are not removed, those affected cannot benefit from these types of therapy.What blockages are involved and how should we proceed?
We first have to go back in history to the discovery of electromagnetic waves and their influence on our pineal gland and hippocampus.Schumann resonance, electromagnetic waves, and their influence on our consciousness
The physicist Prof. Winfried Otto Schumann discovered the so-called Schumann frequencies, “the pulse of the earth”, back in 1950. Research has shown that the rhythm of our brain synchronizes with this. We cannot live without our heartbeat and in the same way, we also need the earth’s heartbeat.
The earth is negatively charged, while the ionosphere is positively charged. This results in a tension between the two.
In 1954, Prof. Schumann reported that frequencies exist in the atmosphere that are located in a cavity between the earth’s surface and the ionosphere. Frequencies between 6-50 HZ exist in this space, while the fundamental frequency is 8 Hz.
A few years later, Prof. Herbert Kénig was able to prove a causal connection between the earth’s frequencies and brain rhythms.
Konig found that alpha waves synchronize with the Schumann frequencies. These are the waves that give us the first deep sleep phases, i.e. slow-wave sleep (SWS).Further scientific studies have shown that the Schumann resonance is a very important electromagnetic wave that influences the biological oscillators in the brain of mammals.
The pineal gland as a magnetic organ calibrates itself with the Schumann frequencies and is harmonized and activated by them.
How does the Schumann resonance affect the earth?
The voltage of these electrostatic fields can increase from 100-300 volts/m in fine weather to 2500-3500 volts/m during thunderstorms! As the voltage increases, so does the intensity of the Schumann frequency. This in turn influences our consciousness.
The pineal gland and the Schumann frequencies
When the pineal gland is in coherence with the Schumann frequencies, the body’s own rhythms are optimally synchronized. These include: heartbeat, respiration, blood pressure, hormone secretion, muscle movement, cell division and electric brain activity.
This means that when we are in a harmonious vibrating state, we are in resonance with the earth. These vibrations correspond to the alpha waves in our brain, i.e. a frequency range between 8 and 13 HZ. It is interesting to note that the Schumann waves not only influence us, but that we in turn also influence the Schumann waves with our brains!Anatomy and histology of the pineal gland
The pineal gland (epiphysis) is located deep between the two halves of the thalamus, in the middle and facing backwards. The pineal gland is therefore in the immediate vicinity of the visual and auditory pathways. This gland is the first organ to develop in the brain, approximately one week after the heart is formed, in the 7th-8th week of pregnancy. In contrast to other brain organs such as the hypothalamus or thalamus, the pineal gland is not connected to the blood-brain barrier. The weight of the pineal gland is 500 to 100 mg, and it is 7-8 mm long and 3-5 mm wide. The pineal gland is the organ with the strongest blood circulation after the kidney.
The pineal gland is visible prenatally from the 36th day. At birth, the pineal gland is already almost fully developed. It directs all glands and has an influence on all hormones and neurotransmitters.
Histology: 90% of the pineal gland consists of pinealocytes, i.e. parenchymal cells of the organ, the remaining 10% are glial cells (astrocytes).
The pineal gland controls all microbiomes that influence all body cells via the cerebrospinal fluid.The hippocampus works closely with the pineal gland.
As a paired organ, the hippocampus is the control center of the limbic system and, together with the olfactory system, makes up the archicortex. There is one hippocampus per hemisphere. It functions as a memory store for autobiographical memories and is located on the inner edge of the temporal lobe. It resembles a seahorse in shape.
The hippocampus is our gateway to the space-time continuum. The hippocampus contains the place and time neurons. As a permanent memory store, the hippocampus has a direct connection to the frontal brain’s short-term memory store, which is responsible for motivation, drive, concentration, focus and decisions. This connection is extremely important.
The hippocampus has limited storage space. Therefore, every night in the first deep sleep phases (slow-wave sleep or SWS), information from the hippocampus is transferred to our larger data storage, i.e. to the neocortical hard drive. This process takes place during the rapid eye movement (REM) phase. In the REM phase, the newly uploaded information is linked to previous experiences without us having to give them up.
According to Prof. Michale Nehls, the hippocampus is the tireless storyteller that transfers new experiences to the neo-cortex (larger memory space) during sleep. As a result, in the morning we are wiser and more experienced after a good and restful nights sleep.
Together with the pineal gland, the hippocampus is also involved in the neuroplasticity of the brain. Neuroplasticity is the brain’s ability to regenerate itself, restructure itself and form new index neurons (Prof. Nehls). The brain is like a muscle. Physical training means an increase in muscle mass, and mental training means an increase in brain volume.
How can we promote neuroplasticity?
Neuroplasticity can be positively influenced by exercise, deep sleep, meditation, creativity and varied work and good thoughts. The desire to learn new things and a good diet are also important in this context.
Anatomy and histology of the hippocampus
What would happen if the hippocampus were to fail?
Case study Henry Gustav Molaison, a man without memory.
The hippocampus gives us social skills and a social memory. These are the basis for being able to live on this earth. The hippocampus is our mental immune system because we learn to recognize dangers through our experiences. If the hippocampus shrinks, then the strong self also shrinks.
New nerve cells are constantly formed every night, without having to give up old experiences. We have managed to survive on this earth by collecting experiences. At the same time, neurogenesis, i.e. the formation of brain cells in the hippocampus, takes place in the early hours of the morning during the REM phase. New index neurons are formed.
What happens if we don’t have a good and deep sleep for a long time?
If, for example, there is no deep sleep due to a lack of melatonin, no index neurons can be formed. This makes us more vulnerable and our mental immune system breaks down. New index neurons ensure that we are curious and that we develop mental resilience and the ability to think in complex ways.
Melatonin not only ensures deep sleep, but melatonin is also one of the most potent growth factors for neurogenesis. Exercise is also crucial for neurogenesis, especially in the fresh air, because during this time many hormones are released that stimulate the growth of free synapses, i.e. the index neurons, during the night.
Why does the pineal gland influence the entire organism?
The pineal gland is considered the pacemaker of the human body. It interacts with other cell systems.
The pineal gland is a neuroendocrine transducer. It receives signals and converts mechanical signals into vivid, surreal and lucid, multisensory images.
Electromechanical fields are converted into bio-mechanical fields and signals cause the pineal gland to produce melatonin. This in turn is responsible for the biorhythm.
Chronobiology has identified around 200 rhythms in the body, and the pineal gland is the clock generator. Consciousness-expanding neurotransmitters are produced in the pineal gland. It is the main rhythm generator.
The pineal gland prevents premature maturation of the gonads in children.
The pineal gland converts L-tryptophan into 5-hydroxytrptophan. Serotonin is then produced from this.
Serotonin in turn is converted to N-acetyl-serotonin in further chemical reactions. It then converts into melatonin.
Melatonin induces the REM sleep phase (Rapid-Eye Movement)
Corticoid from NNR and melatonin are in an inverse relationship to each other.
The pineal gland is the antenna to a higher consciousness. It has to do with mood and consciousness.
Stress prevents sleep! Stress blocks the pineal gland! Stress blocks neuroplasticity!
What is stress and how can you prevent it?
In 1936, the term stress was transferred from the field of metal work to medicine. The term was used when metals were subjected to a certain amount of tension during processing, making further processing more difficult.
Hans Selye, a physician of Hungarian descent born in Vienna in 1907, who later emigrated to Canada, had experienced such tensions in his patients. He saw that these tensions manifested themselves in various clinical pictures and complaints such as chest pain, muscle pain or headaches.Coping with the stressful situations that occur repeatedly and increasingly in modern society is an energy-consuming process. It places additional strain on the already fatigued mitochondria by synthesizing adenosine triphosphates.
In this lecture we learned that these processes are complicated by external factors such as environmental factors and inadequate recovery of the body during the night.Stress involves blockages, both on a physical and energetic level.
Blockages prevent the organism from entering a healing process. One of the most important and first steps in therapy is therefore to remove these blockages.
In this context, | have conducted several experiments over the last 3-4 years and have come up with the following therapy concepts:Ethereal treatment in three phases
For whom is an ethereal treatment useful?
These three phase treatments are useful for all of us. However, they are particularly suitable for people with severe sleep disorders, inner restlessness, emotionally induced cardiac arrhythmia, tinnitus and, above all, for people with anxiety, worry and grief. Due to the current situation, many people are tense and can therefore make good use of such a treatment. All patients who suffer from constantly recurring infections which could not be successfully treated with previous therapies are also eligible.Preparation for ethereal treatments
The black flexible applicator is connected to the black cable and placed on the corresponding chakra. You can generally place the applicator on the abdomen at the level of the solar plexus. Hand and foot applicators should also be connected to the black cable. Both hands and both feet are placed on the applicators. If the forehead chakra or crown chakra is involved, the narrow long applicator should also be connected to the black cable and placed around the head at the level of
the ears. The square applicator is placed on the crown of the head.1st session of ethereal treatment:
Program 131.0 — Basic program Yang – 3 minutes
Program 918.0, 3084.0 – Release energetic blockages – 3 minutes each, i.e. 6 minutes in total
Program 700.3 — Geopathy balance – 3 minutes
Program 3094.0 – Shock treatment – 3-5 minutes2nd session of ethereal treatment:
Program 131.0 — Basic program Yang – 3 minutes
Program 430.2, 480.1, 930.3 – General detoxication – 3 minutes each, i.e. 9 minutes in total
Program 3084.0 — Stress reduction – 3 minutes3rd session of ethereal treatment:
Program 131.0 — Basic program Yang – 3 minutes
Program 970.4 – Toxin elimination – 3 minutes
Program 422.7 – Implant aftercare – 3 minutes
Program 402.1 – Cell stimulation (reaction weakness) – 3 minutes
Program 527.2 – Tinnitus – 3 minutesThank you for your attention!
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